Category genetics

Apr 17 2023

Body Suit by Suzanne Hagelin

Titles are important, as is the case with this trilogy opening novel’s title, but I almost didn’t read this one. Body Suit? Sounds like a fashion mistake from my youth. Once I began, the narrative style didn’t grab me from the outset, as the point-of-view characters switched back and forth between a soon to be indentured servant/colonist and a rather prissy seller of space suits. Hold on, y’all, because it gets better! Or maybe the author’s style grew on me. Anyway, the switching back and forth continues as the two-fold adventure develops, but each character fleshes out so well that I genuinely enjoyed each character’s time as POV.

The purchaser of the body suit, Silvariah Frandelle, initially travels to a space station called Guam, where she learns both how to navigate being a servant (called a Contractor in the book) and how to use the fancy body suit of the title, and then to Mars, as a miner at the new Resnik colonial facility. Back on Earth Walter Cuevas, who sold the suit for far less than its MSRP in exchange for some tips on how the suit performs, learns to act on the suggestions that the business savvy Sil Frandelle communicates to him. His fortunes grow by leaps and bounds as Sil helps him get lucrative advertising deals, then offers tips on which stocks to purchase based on her observations while in space.

Both Sil and Walter must deal with Artificial Intelligence entities, too. Sil is introduced to the Companion while on Guam, and the AI is also present with her on Mars. The Companion is really her Taskmaster, but the programmers chose a more benevolent title for the AI, as its job is multifunctional, assessing (or perhaps spying on) her, while also directing her industrial activities on behalf of those who own her contract. Walter, as he grows more wealthy entrusts Daisy, a personal assistant AI who is styled as a young female human, to assist him in his business matters as well as being a loyal and undemanding companion, unlike his ex-wife. But, like any program, even a personal assistant can be hacked….

There are almost too many minor characters to keep straight, quite a bit of action, and sufficient suspense to keep the reader swiping the pages. Sil’s stay on Mars only starts out boring. The plot moves along quite well, actually. I really liked this story, once I got into it, and I am tempted to buy the rest of the trilogy, although the book stands alone well-enough.

Body Suit is science fiction, obviously, but in the manner of great sci-fi, because it delves into some really controversial aspects of the role of artificial intelligence in society. As programs such as Chat-GPT are growing in popularity, the moral questions broached in this novel are timely. Without spoiling the suspense with specifics, the novel also touches on how eugenics might change society, too. But, more than that, there are some interesting word choices in this novel, which let the reader know that some thought went into this one! I highly recommend it.

Oct 8 2021

Walter Issacson’s The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race

This is a big book in so many ways. Walter Isaacson is known for in-depth biographies of such diverse people as Steve Jobs, Leonardo da Vinci, and Benjamin Franklin, so he is certainly a “big name” author. The book itself is 485 pages long, not including the notes, which brings the page count to 536. As the sub-title indicates, the central figure in this book is Jennifer Doudna, but many, many others have significant roles in this not so brief history of CRISPR (which can be loosely defined as a way to edit genes.)

Jennifer Doudna grew up in Hawaii, the eldest daughter of a college professor. Her father, who doted on her, once left her a copy of Watson’s book on DNA, The Double Helix, and she mentions this book as one of the reasons she pursued a career as a scientist, despite being told by her high school guidance counselor that “women don’t do science.” Rather obviously, she not only did science, but she has done it well enough to earn the Nobel Prize in 2020.

In The Codebreaker, Isaacson follows Doudna’s career, but intersperses it with pertinent information about the gradual unfolding of modern genetic studies, along with brief sketches of the scientists and scholars who influenced Doudna’s work. Two terms which come up over and over are RNA, which is the “worker bee” that carries out many functions in life, and CRISPR, which has to do with the structures which help organisms adapt to needed change (such as when bacteria “learns” to resist a virus.)

There are a lot of pages in this book devoted to what was discovered, by whom, when, and who managed to get published first. That’s the nature of academia. Then there’s the quest for patents and prize money, which is how some academic institutions manage to pay for enormous labs and pay their large supporting staff. Again, this is a book that is about more than a single researcher. Over and over, Isaccson stresses the importance of collaboration in modern science.

There are some really important concepts discussed in the later chapters, including the ethics of manipulating human genes. One researcher took it upon himself to edit the offspring of Chinese couples in an attempt to eliminate the possibility that they could have HIV, which is apparently quite shunned in modern Chinese culture. Other possible reasons to edit offspring would be to eradicate such conditions as Huntington’s disease, which ends in a horrible decline before inevitable death. Eliminating genetic diseases are worthy uses for CRISPR and other genetic engineering, where is the line? Should prospective parents be able to choose the genetic characteristics such as height, intellect, or even hair color of their offspring they way we might choose dishes in a cafeteria? A number of scientists, including Doudna, have had many meetings, discussing such topics, and these are summarized in The Code Breaker.

When the nasty CV hit, a situation that the author sometimes describes as “the plague year,” many of the scientists mentioned in this book, including Doudna, put aside their competition for prizes and first published honors, and collaborated to produce accurate and rapid tests for the pesky illness. Then, in short order, they turned to prevention, and the mRNA vaccines. Not only were these vaccines quick to develop, they also lay the groundwork for more to come, as the same techniques might be used to prevent other illnesses.

The Code Breaker is more than a biography, as the title states, and it is a longish, sometimes challenging book, but like other works by Walter Issacson, ultimately quite rewarding. It isn’t cheap to buy, compared to many of the books I read, nor is it “light reading.” Like a gourmet meal, it is complex, memorable, and enjoyable. Readers are urged to read, then think, and ultimately savor this work.